![]() ![]() Finally, we show that Smaug acts as a positive regulator of Hedgehog signaling during wing morphogenesis. Importantly, we demonstrate in vivo that HH reduces the levels of smaug mRNA and increases the level of several mRNAs downregulated by Smaug. The activation of Fused and its binding to Smaug are sufficient to suppress its ability to form cytosolic bodies and to antagonize its negative effects on endogenous targets. These effects rely on the interaction of Smaug with the G‐protein coupled receptor Smoothened, which promotes the phosphorylation of Smaug by recruiting the kinase Fused. We show that Smaug's protein levels and mRNA repressive activity are downregulated by Hedgehog signaling in tissue culture cells. ![]() However, the regulation of its activity remains poorly understood. ![]() From fly to mammals, the Smaug/Samd4 family of prion‐like RNA‐binding proteins control gene expression by destabilizing and/or repressing the translation of numerous target transcripts. ![]()
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